Current Advances In Drug Delivery Through Fast Dissolving Disintegrating Dosage Forms

Books about Design & Development of Fast Dissolving Tablets Using Novel Techniques

Books about "Fast dissolving tablets "

Fast Dissolving/Disintegrating Dosage Forms (FDDFs) have been commercially available since the late 1990s. FDDFs were initially available as orodispersible tablets, and later, as orodipsersible films for treating specific populations (pediatrics, geriatrics, and psychiatric patients). Granules, pellets and mini tablets are among latest additions to these dosage forms, which are still in the development pipeline. As drug delivery systems, FDDFs enable quicker onset of action, immediate drug delivery, and sometimes offer bioavailability benefits due to buccal/sublingual absorption. With time, FDDF have evolved to deliver drugs in a sustained and controlled manner. Their current market and application is increasing in demands with advances in age adapted dosage forms for different patients and changing regulatory requirements that warrant mandatory assessments of new drugs and drug products before commercial availability. This book presents detailed information about FDDFs from their inception to recent developments. Readers will learn about the technical details of various FDDF manufacturing methods, formulation aspects, evaluation and methods to conduct clinical studies. The authors also give examples of marketed fast disintegrating/dissolving drug products in US, Europe, Japan, and India. This reference is ideal for pharmacology students at all levels seeking information about this specific form of drug delivery and formulation.

The main purpose of this research was to develop orodispersible tablets containing Phikud Navakot Extract (NVK-E) with consistent quality and convenience. Phikud Navakot is a traditional Thai herbal medicine that has been used in Thailand for more than 100 years. Preformulation studies of NVK-E and excipients were carried out. High performance liquid chromatography (HPLC) method was validated according to AOAC Guidelines for Dietary Supplements and Botanicals to determine existing three analytical markers, i.e. gallic acid, vanillic acid and ferulic acid. The viscous NVK-E was transformed to more processable powder by adsorption on the selected excipient. Orodispersible tablets containing NVK-E were developed by direct compression method using three superdisintegrants, i.e. Polyplasdone® XL-10, Explotab® and Ac-Di-Sol® at different percentages of 2%, 6% and 10% in formulations. Quality control of tablets were performed. The stability study of the chosen formulation was evaluated in the intended package for commercialization according to ASEAN Guideline on Stability Study of Drug Product under accelerated and long term storage conditions. At 3 months under accelerated storage condition, more than 5% deviated from initial values which failed to meet the requirement. However, at 3 and 6 months under long term storage condition, analytical markers still retained values of not

In a finished nutraceutical product, flavors play an integral role. Flavor Development for Functional Foods and Nutraceuticals is about the crucial role added flavors play in any nutraceutical product. It describes the various extraction techniques that are being adopted for manufacturing flavors from natural raw materials. Yield and retention of aromatic components during several extraction methods and flavor encapsulation techniques for thermal degradable food components are discussed. Advanced methods of flavor extraction techniques like supercritical C02 extraction are emphasized. The safety and quality aspects of flavor incorporation in food processing industries are reviewed with respect to international regulations. The importance of flavor in the nutraceuticals industry is also discussed. In addition, the book stresses the functional value and organoleptic acceptability towards product optimization/formulation. Features: Explains how flavors play an integral role in a finished nutraceutical product Describes the various extraction techniques that are being adopted for manufacturing flavors from natural raw materials Covers flavor encapsulation techniques for thermal degradable food components Provides an introduction to the history of how some natural flavor ingredients, botanicals, and extracts were used in ancient times in Ayurveda and herbal medicine This is an ideal reference book for the flavor chemists, food scientists, nutraceutical formulators,

Seit dem Inkrafttreten der EU-Verordnung über Kinderarzneimittel besteht ein erhohter Bedarf an kindgerechten Arzneiformen. Der in den letzten Jahren angestoßene Paradigmenwechsel weg von flüssigen hin zu festen oralen Darreichungsformen erfordert die Entwicklung fester Darreichungsformen, die schon bei Sauglingen und Kleinkindern angewendet werden können. Daher wird in der vorliegenden Arbeit als neuer Ansatz die Orodispersible Minitablette (ODMT) vorgestellt, die Orodispersible Tabletten mit Minitabletten kombiniert. Es konnten erstmals arzneistofffreie ODMTs mit dem gebrauchsfertigen Hilfsstoff LudiflashR mit einer ausreichenden Bruchkraft von 8 N und gleichzeitig kurzer Benetzungszeit _ 3 s, entwickelt werden. Darüber hinaus konnten ODMTs mit LudiflashR und Hydrochlorothiazid in kindgerechten Dosierungen hergestellt werden. Diese Zubereitungen zeigten eine zerfallsabhängige Wirkstofffreisetzung, die mit Hilfe einer selbstständig entwickelten Freisetzungsapparatur demonstriert werden konnte. Der erstmals durchgeführte Vergleich von fünf kommerziellen gebrauchsfertigen Hilfsstoffen (LudiflashR, PearlitolR Flash, ParteckR ODT, ProsolvR ODT und PharmaburstR 500) zeigte vielfaltige Unterschiede der ODMTs hinsichtlich der Zerfallszeiten und der mechanischen Eigenschaften. Die anschliesend hergestellten ODMTs mit Hydrochlorothiazid entsprachen den Vorgaben des Europäischen Arzneibuchs hinsichtlich der Gleichförmigkeit des Gehalts einzeldosierter Arzneiformen. Der Arzneistoff-Gehalt blieb über einen Lagerungszeitraum von sechs Monaten unter Stressbedingungen konstant. Mit vier von fünf Hilfsstoffen konnten außerdem ODMTs mit einer vollständigen Arzneistofffreisetzung _ 15 Minuten entwickelt werden. Die verwendeten Hilfsstoffprodukte

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