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Development Of Mouth Dissolving Tablets

Development Of Mouth Dissolving Tablets
Author: Biswajit Basu
Publisher:
ISBN: 9783659887482
Size: 30.66 MB
Format: PDF
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Development of Mouth Dissolving Tablets
Language: en
Pages: 188
Authors: Biswajit Basu
Categories:
Type: BOOK - Published: 2016-06-07 - Publisher:
Books about Development of Mouth Dissolving Tablets
Current Advances in Drug Delivery Through Fast Dissolving/Disintegrating Dosage Forms
Language: en
Pages: 515
Authors: Vikas Anand Saharan
Categories: Medical
Type: BOOK - Published: 2017-05-11 - Publisher: Bentham Science Publishers
Fast Dissolving/Disintegrating Dosage Forms (FDDFs) have been commercially available since the late 1990s. FDDFs were initially available as orodispersible tablets, and later, as orodipsersible films for treating specific populations (pediatrics, geriatrics, and psychiatric patients). Granules, pellets and mini tablets are among latest additions to these dosage forms, which are still in the development pipeline. As drug delivery systems, FDDFs enable quicker onset of action, immediate drug delivery, and sometimes offer bioavailability benefits due to buccal/sublingual absorption. With time, FDDF have evolved to deliver drugs in a sustained and controlled manner. Their current market and application is increasing in demands with advances in age adapted dosage forms for different patients and changing regulatory requirements that warrant mandatory assessments of new drugs and drug products before commercial availability. This book presents detailed information about FDDFs from their inception to recent developments. Readers will learn about the technical details of various FDDF manufacturing methods, formulation aspects, evaluation and methods to conduct clinical studies. The authors also give examples of marketed fast disintegrating/dissolving drug products in US, Europe, Japan, and India. This reference is ideal for pharmacology students at all levels seeking information about this specific form of drug delivery and formulation.
Development of Fast Dissolving Tablets
Language: en
Pages: 156
Authors: Basavaraj Nanjwade, Sachin A. Thakare
Categories: Medical
Type: BOOK - Published: 2011-12 - Publisher: LAP Lambert Academic Publishing
Oral drug delivery has been known for decades the most widely utilized route for administration among all the route that have been explored for systemic delivery of drugs via various pharmaceutical products of different dosage forms. The reasons that the oral route has achieved such popularity may be in part attributed to its ease of administration as well as the traditional belief that by oral administration the drug is well absorbed as the food stuffs that are ingested daily. In fact, the development of a pharmaceutical product for oral delivery, irrespective of its physical form involves varying extents of optimization of dosage form characteristics within the inherent constraints of GI physiology. Therefore, a fundamental understanding of various disciplines, including GI physiology, pharmacokinetics, pharmacodynamics and formulation design are essential to achieve a systemic approach to successful development of an oral pharmaceutical dosage form. The more sophisticated a delivery system, the greater is the complexity of these various disciplines involved in the design and optimization of the system. In any case, the scientific framework required for the successful development.
Design and Development of Sildenafil Citrate
Language: en
Pages: 108
Authors: Dhaval Patel, Mukesh Patel, Kanu Patel
Categories: Medical
Type: BOOK - Published: 2013 - Publisher: LAP Lambert Academic Publishing
Oral drug delivery is the most widely utilized route of administration among the entire route that has been explored for the systemic delivery of drug via various pharmaceutical products of different dosage form. The conventional tablet seems to be most popular because of its ease of transportation and low manufacturing cost as compare to others but poor patient compliance with whom experienced swallowing difficulties. In response to this mouth dissolving drug delivery system (MDDs) were developed as an alternative to tablet, capsule and syrup. A variety of MDDs like Mouth dissolving tablets (MDTs) and Mouth dissolving films (MDFs) were commercialized. This book describes the design and development of sildenafil citrate mouth dissolving film. As sildenafil citrate is a widely utilized drug for erectile dysfunction. This produced mouth dissolving film prepared by newer polymer Kollicoat protect and showed the good alternative for the other mouth dissolving film former, specially HPMC. Stevioside a natural sweetener used and showed the potency to mask the bitter taste of sildenafil citrate. Hence, MDF of sildenafil citrate provide good alternate to other available dosage form.
Development and Evaluation of Fast Dissolving Tablet of Loratadine
Language: en
Pages: 120
Authors: Nidhi Sherathiya, Naisarg Pujara, Sumit Doshi
Categories: Medical
Type: BOOK - Published: 2013 - Publisher: LAP Lambert Academic Publishing
Loratadine is a non sedative anti-histaminic drug. Its major use is in control of congestion, sneezing, runny nose and itching that a patient suffers with an allergic attack or an infection. It has poor solubility in water. Therefore, the solubility and drug release were enhanced using the solid dispersion technique and fast dissolving tablet were formulated. Solid dispersion prepared using Poloxamer 407, PEG 6000 and urea. The solid dispersion were evaluated for saturation solubility, drug content and in vitro dissolution study and it was characterized using FT-IR, X-RD, SEM and DSC study. The fast dissolving tablets of loratadine was formulated using crospovidone and crosscarmelose sodium by direct compression method. The tablets were evaluated for thickness, hardness, weight variation, friability, disintegration time and % in vitro drug release. A 32 factorial design was used to study the effect of Loratadine: Poloxamer 407 and crospovidone on disintegration time and % in vitro drug release. The responses were analyzed using ANOVA. The obtained model was validated & optimized formulation was prepared as suggested by the software.
Design & Development of Fast Dissolving Tablets Using Novel Techniques
Language: en
Pages: 248
Authors: Upendra Kulkarni, Raghunandan Deshpande, Gulam Rabbani
Categories: Medical
Type: BOOK - Published: 2019-08-28 - Publisher:
Books about Design & Development of Fast Dissolving Tablets Using Novel Techniques
Language: en
Pages:
Authors: Dr.G.SANDHYARANI Guggilla
Categories: Medical
Type: BOOK - Published: - Publisher: Lulu.com
Books about "Fast dissolving tablets "
Development & Characterization of
Language: en
Pages: 112
Authors: Rajinder Mann, Imran Khan, Amit Chandna
Categories: Medical
Type: BOOK - Published: 2016-07-26 - Publisher:
Books about Development & Characterization of
Pharmaceutical Dosage Forms - Tablets
Language: en
Pages: 1552
Authors: Larry L. Augsburger, Stephen W. Hoag
Categories: Medical
Type: BOOK - Published: 2016-04-19 - Publisher: CRC Press
The ultimate goal of drug product development is to design a system that maximizes the therapeutic potential of the drug substance and facilitates its access to patients. Pharmaceutical Dosage Forms: Tablets, Third Edition is a comprehensive resource of the design, formulation, manufacture, and evaluation of the tablet dosage form, an
Formulation Development of Taste Masked Cefuroxime Axetil
Language: en
Pages: 108
Authors: Nilofer Sayyed, Kiran Bhise
Categories: Medical
Type: BOOK - Published: 2015-04-23 - Publisher: LAP Lambert Academic Publishing
The objective of the present study was to address challenges in research and development associated with the bitter taste and poor aqueous solubility of Cefuroxime Axetil. The inclusion complex of drug and HP- -Cyclodextrin and mouth dissolving tablets were prepared. Bitter taste threshold, DSC, PXRD, saturation solubility, in-vitro dissolution studies were carried out for pure drug CA, commercial tablet CEFTUM and CA loaded MDTs. The results support an addition of banana starch to CA-HP CD inclusion complexes can efficiently aid as an antidiarrheal agent and mask the bitter taste of CA."