Nucleosides And Nucleotides As Antitumor And Antiviral Agents


Nucleosides And Nucleotides As Antitumor And Antiviral Agents
Author: D.C. Baker
Publisher: Springer
ISBN: 1461528240
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Nucleosides And Nucleotides As Antitumor And Antiviral Agents

eBook File: Nucleosides-and-nucleotides-as-antitumor-and-antiviral-agents.PDF Book by D.C. Baker, Nucleosides And Nucleotides As Antitumor And Antiviral Agents Books available in PDF, EPUB, Mobi Format. Download Nucleosides And Nucleotides As Antitumor And Antiviral Agents books, Due to the worldwide epidemic of acquired immunodeficiency syndrome (AIDS), the past ten years have witnessed a flurry of activity in the chemotherapy of viral diseases. Unprecedented scientific efforts have been made by scientists and clinicians to combat infections of human immunodeficiency virus (HIY), the causative agent. Looking back over the past ten years, we have made remarkable progress toward the treatment of the viral disease: isolation of HIV only two years after the identification of the disease, plus major strides in the areas of the molecular biology and virology of the retrovirus, etc. More remarkably, the discovery of the chemotherapeutic agent AZT (Retrovir) was made within two years after the isolation and identification of the virus, followed by unprecedented drug development efforts to culminate in the FDA approval of AZT in twenty-three months, which was a record-breaking time for approval of any drug for a major disease. The last six to seven years have particularly been an exciting and productive period for nucleoside chemists. Since the activity of AZI' was established in 1985, nucleoside chemists have had golden opportunities to discover additional anti-HIV nucleosipes, which are hoped to be less toxic and more effective than AZT, and the opportunity continues. As we all are aware, AZT possesses extremely potent anti-HIY activity, and no other nucleoside or non nucleoside has surpassed the potency of AZT in vitro.


Nucleosides and Nucleotides as Antitumor and Antiviral Agents
Language: en
Pages: 336
Authors: D.C. Baker, C.K. Chu
Categories: Medical
Type: BOOK - Published: 2013-11-11 - Publisher: Springer
Due to the worldwide epidemic of acquired immunodeficiency syndrome (AIDS), the past ten years have witnessed a flurry of activity in the chemotherapy of viral diseases. Unprecedented scientific efforts have been made by scientists and clinicians to combat infections of human immunodeficiency virus (HIY), the causative agent. Looking back over the past ten years, we have made remarkable progress toward the treatment of the viral disease: isolation of HIV only two years after the identification of the disease, plus major strides in the areas of the molecular biology and virology of the retrovirus, etc. More remarkably, the discovery of the chemotherapeutic agent AZT (Retrovir) was made within two years after the isolation and identification of the virus, followed by unprecedented drug development efforts to culminate in the FDA approval of AZT in twenty-three months, which was a record-breaking time for approval of any drug for a major disease. The last six to seven years have particularly been an exciting and productive period for nucleoside chemists. Since the activity of AZI' was established in 1985, nucleoside chemists have had golden opportunities to discover additional anti-HIV nucleosipes, which are hoped to be less toxic and more effective than AZT, and the opportunity
Zeitschrift Für Naturforschung
Language: de
Pages:
Authors: D.C. Baker, C.K. Chu
Categories: Chemistry
Type: BOOK - Published: 1999 - Publisher:
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Pages: 821
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Language: en
Pages:
Authors: Weimin Liu
Categories: Chemistry
Type: BOOK - Published: 1997 - Publisher:
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Synthesis, Chemical Reactivity, and Biological Evaluation of Pyrazinoic Acid C-nucleosides
Language: en
Pages:
Authors: John Andrew Walker
Categories: Chemistry
Type: BOOK - Published: 1996 - Publisher:
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Language: en
Pages:
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Categories: Biology
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Language: en
Pages:
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Categories: Chemistry
Type: BOOK - Published: 1999-10 - Publisher:
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Language: en
Pages:
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Categories: Engineering
Type: BOOK - Published: 1996 - Publisher:
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Organic Synthesis Via Organometallics (OSM5)
Language: en
Pages: 376
Authors: Günter Helmchen
Categories: Mathematics
Type: BOOK - Published: 1997-06-26 - Publisher: Springer
Vom 26. - 28.9.1996 fand in Heidelberg die abschließende Tagung der OSM-Reihe zum Thema der "Organischen Synthesechemie mit Hilfe von Organometallreagenzien" statt, auf denen alle von der VW-Stiftung über 10 Jahre geförderten Arbeitsgruppen und einige geladene ausländische Wissenschaftler über ihre spannenden Forschungsergebnisse berichteten und diskutierten. Die hochkarätig besetzten Vortragsreihen finden ihre schriftliche Dokumentation in diesem Forschungsband, der in keiner Wissenschaftsbibliothek fehlen darf. Organometallic chemistry and homogeneous catalysis with transition metal complexes are of increasing importance in organic synthesis. Methods from these areas allow the control of regio- and stereoselectivity with ever increasing efficiency. Recent progress and state of the art in the field are documented in this volume which covers the lectures delivered at the 5th symposium "Organic Synthesis via Organometallics" held in Heidelberg. A selection of 13 plenary and 10 invited lectures present a broad survey on new avenues in organic synthesis including timely topics such as polymer synthesis via organometallics, synthesis of new organometallics, mechanism of catalytic processes, asymmetric catalysis of carbon bond forming reactions and stereoselective synthesis of biologically active compounds.
Handbook for Grants Assistants
Language: en
Pages: 276
Authors: National Institutes of Health (U.S.). Division of Research Grants. Referral and Review Branch
Categories: Federal aid to medical research
Type: BOOK - Published: 1987 - Publisher:
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