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Eigenschaften Der Protein Z Und Protein Z Abh Ngigen Protease Inhibitor Defizienz W Hrend Einer Generalisierten Shwartzman Reaktion

Protein Protease Inhibitor
Author: Philipp Nagel
Publisher:
ISBN:
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Untersucht wurden Protein Z (PZ)- sowie Protein Z abhängige Protease Inhibitor (ZPI)-defiziente Mäuse während einer generalisierten Shwartzman Reaktion (GSR). Eine PZ-Defizienz bewirkte nach Induktion der GSR eine aggravierte Immunreaktion, gekennzeichnet durch eine akzelerierte, transendotheliale Leukozyten-Migration, konsekutiv frühzeitiger Leukozytopenie sowie durch ein akzentuiertes pro- und antiinflammatorisches Zytokinprofil. In den ZPI-defizienten Tieren stellte sich eine aggravierte, septische Koagulopathie dar mit akzelerierter Ausbildung einer disseminierten intravasalen Gerinnung.ger
Eigenschaften der Protein Z- und Protein Z abhängigen Protease Inhibitor-Defizienz während einer generalisierten Shwartzman Reaktion
Language: de
Pages:
Authors: Philipp Nagel
Categories:
Type: BOOK - Published: 2019 - Publisher:
Untersucht wurden Protein Z (PZ)- sowie Protein Z abhängige Protease Inhibitor (ZPI)-defiziente Mäuse während einer generalisierten Shwartzman Reaktion (GSR). Eine PZ-Defizienz bewirkte nach Induktion der GSR eine aggravierte Immunreaktion, gekennzeichnet durch eine akzelerierte, transendotheliale Leukozyten-Migration, konsekutiv frühzeitiger Leukozytopenie sowie durch ein akzentuiertes pro- und antiinflammatorisches Zytokinprofil. In den ZPI-defizienten Tieren stellte sich eine aggravierte, septische Koagulopathie dar mit akzelerierter Ausbildung einer disseminierten intravasalen Gerinnung.ger
Protein Protease Inhibitor
Language: en
Pages: 481
Authors: Keitarō Hiromi
Categories: Streptomyces subtilisin inhibitor
Type: BOOK - Published: 1985 - Publisher: Elsevier Publishing Company
Books about Protein Protease Inhibitor
Proteinase Inhibitors
Language: en
Pages: 661
Authors: Alan J. Barrett, G. Salvesen
Categories: Antiprotéases
Type: BOOK - Published: 1986 - Publisher: Elsevier Publishing Company
The twelfth volume in this well established series presents the latest research on proteinases, which are known or suspected to be implicated in many aspects of normal physiology and disease processes. In order to understand the nature of this involvement the researcher must repeatedly resort to our current understanding of proteinase inhibitors. The chapters in this book cover various approaches to the investigation and treatment of a wide variety of medical problems, including malignancy, arthritis, hypertension and coagulation disorders, viral, bacterial and parasitic infections, muscular dystrophy, pulmonary emphysema and neurological disease. Due to the level of sophistication of naturally occurring protein inhibitors, techniques such as X-ray crystallography are being used intensively, and the results are being fed back into the design of artificial inhibitors made chemically or by genetic engineering. Rapid technical progress in these synthetic methods encourages the full use of new information available, and the outcome is that a range of new drugs are in the stage of pre-clinical trials.
Protein Protease Inhibitor
Language: en
Pages: 481
Authors: Keitarō Hiromi
Categories: Streptomyces subtilisin inhibitor
Type: BOOK - Published: 1985 - Publisher: Elsevier Publishing Company
Books about Protein Protease Inhibitor
Viral Proteases and Antiviral Protease Inhibitor Therapy
Language: en
Pages: 132
Authors: Uwe Lendeckel, Nigel M. Hooper
Categories: Medical
Type: BOOK - Published: 2009-06-19 - Publisher: Springer Science & Business Media
The 8th volume in the Proteases in Biology and Disease series focuses on the role of proteases in virus function and their potential as anti-viral targets. Viral infections are still difficult to threat and some remained life-threatening diseases in spite of antiviral drug research over decades. Proteases are still regarded as an Achilles’ heel of the pathogens and, thus, protease inhibitors may help to handle the known and the emerging viral threads. The book discusses viral proteases of the most important pathogenic viruses, responsible for severe diseases: AIDS, SARS, Hepatitis, Cytomegalovirus, T-cell lymphotropic virus, Picornavirus. This book focuses specifically on the viral proteases, crucial prerequisites for viral entry into cells and viral replication. Viral proteases represent an important pharmaceutical target. The current stage of protease inhibitor development and therapy are summarised and discussed by experts in the field. This volume represents a timely and valuable continuation of the Proteases in Biology and Disease series. The reader will learn the potential for proteases as targets for effective anti-virals. This book will be a valuable source of information on viral proteases and provoke further research in this important field.
Development of FRET Technology of Protein-protein Interactions by Using Protease Inhibitor System
Language: en
Pages: 146
Authors: Laura Gómez Cuadrado, Borut Štrukelj, Branka Javornik, Polona Jamnik
Categories: Medical
Type: BOOK - Published: 2013 - Publisher:
Books about Development of FRET Technology of Protein-protein Interactions by Using Protease Inhibitor System
Proteases and Protease Inhibitors in Alzheimer's Disease Pathogenesis
Language: en
Pages: 259
Authors: Carl D. B. Banner, Ralph A. Nixon
Categories: Science
Type: BOOK - Published: 1992 - Publisher:
These 22 papers cover protein trafficking, lysosomal proteolysis, calpains, serpins, processing of cytoskeletal proteins, and complex proteolytic cascades of the circulatory system.
Protease Inhibitors: Advances in Research and Application: 2011 Edition
Language: en
Pages: 65
Authors: Carl D. B. Banner, Ralph A. Nixon
Categories: Medical
Type: BOOK - Published: 2012-01-09 - Publisher: ScholarlyEditions
Protease Inhibitors: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Protease Inhibitors in a concise format. The editors have built Protease Inhibitors: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Protease Inhibitors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Protease Inhibitors: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Proteases: Structure and Function
Language: en
Pages: 564
Authors: Klaudia Brix, Walter Stöcker
Categories: Science
Type: BOOK - Published: 2014-01-21 - Publisher: Springer Science & Business Media
Proteolysis is an irreversible posttranslational modification affecting each and every protein from its biosynthesis to its degradation. Limited proteolysis regulates targeting and activity throughout the lifetime of proteins. Balancing proteolysis is therefore crucial for physiological homeostasis. Control mechanisms include proteolytic maturation of zymogens resulting in active proteases and the shut down of proteolysis by counteracting endogenous protease inhibitors. Beyond the protein level, proteolytic enzymes are involved in key decisions during development that determine life and death – from single cells to adult individuals. In particular, we are becoming aware of the subtle role that proteases play in signaling events within proteolysis networks, in which the enzymes act synergistically and form alliances in a web-like fashion. Proteases come in different flavors. At least five families of mechanistically distinct enzymes and even more inhibitor families are known to date, many family members are still to be studied in detail. We have learned a lot about the diversity of the about 600 proteases in the human genome and begin to understand their physiological roles in the degradome. However, there are still many open questions regarding their actions in pathophysiology. It is in this area where the development of small molecule inhibitors as therapeutic
Proteases in Health and Disease
Language: en
Pages: 328
Authors: Enrico Di Cera
Categories: Science
Type: BOOK - Published: 2011-03-07 - Publisher: Academic Press
Proteases occur naturally in all organisms. They are enzymes that are involved in many physiological reactions such as digestion of food and blood clotting. This volume reviews their role in health and disease and presents the latest research and developments. * Discusses new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields